The Pathogenesis of Autoimmune Liver Disease
نویسندگان
چکیده
منابع مشابه
The Pathogenesis of Autoimmune Liver Disease.
BACKGROUND Autoimmune liver disease (AILD) encompasses 3 main distinct clinical diseases: autoimmune hepatitis, primary biliary cholangitis (formally known as cirrhosis, PBC) and primary sclerosing cholangitis (PSC). These conditions are an important, yet under-appreciated cause of patient morbidity and mortality with ongoing unmet needs for further research and clinical advances. KEY MESSAGE...
متن کاملAutoimmune Disease: Pathogenesis
Autoimmune diseases are the result of specific immune responses directed against structures of the self (Burnet and Fenner, 1949). The organism possesses powerful mechanisms to avoid immune autoaggression. The acquired ability of the immune system to avoid responsiveness to self antigens is defined as ‘tolerance’, and is obtained by the cooperative efforts of central and peripheral mechanisms, ...
متن کاملMultistep Pathogenesis of Autoimmune Disease
In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune dise...
متن کاملAutoimmune liver disease.
• The diagnosis of autoimmune hepatitis is based on specific immunological, histological and biochemical characteristics after exclusion of other causes of liver disease including viral hepatitis. • Hepatitis E virus infection should be considered in the differential diagnosis of autoimmune hepatitis. • Prednisone, prednisolone, or budesonide are first line treatment options for autoimmune hepa...
متن کاملAutoimmune liver disease
Autoimmunity is regarded as the main mechanism involved in pathogenesis of various liver diseases, such as autoimmune hepatitis (ÁIÇ), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), autoimmune cholangitis, overlap syndromes AIH-PBC and AIH-PSC and liver dysfunction due to connective tissue diseases. Autoimmune hepatitis is an immune-mediated, autodestructive liver diseas...
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ژورنال
عنوان ژورنال: Digestive Diseases
سال: 2016
ISSN: 0257-2753,1421-9875
DOI: 10.1159/000444471